Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic β-cells overexpressing UCP2
نویسندگان
چکیده
منابع مشابه
Nuclear Hormone Receptor RXR Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells
From the 1 Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan; the 2 Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan; and the 3 Section on Molecular Genetics of Immunity, Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institute...
متن کاملSerotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy.
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell. Mechanisms have been proposed for the increased β cell mass, but not for the increased GSIS. Because serotonin production increases dramatically during pregnancy, we tested whether flux through the ionotropic 5-HT3 ...
متن کاملInterleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells
OBJECTIVE Interleukin-6 (IL-6) has a significant impact on glucose metabolism. However, the effects of IL-6 on insulin secretion from pancreatic β-cells are controversial. Therefore, we analyzed IL-6 effects on pancreatic β-cell functions both in vivo and in vitro. RESEARCH DESIGN AND METHODS First, to examine the effects of IL-6 on in vivo insulin secretion, we expressed IL-6 in the livers o...
متن کاملA subcellular model of glucose-stimulated pancreatic insulin secretion.
When glucose is raised from a basal to stimulating level, the pancreatic islets respond with a typical biphasic insulin secretion pattern. Moreover, the pancreas is able to recognize the rate of change of the glucose concentration. We present a relatively simple model of insulin secretion from pancreatic beta-cells, yet founded on solid physiological grounds and capable of reproducing a series ...
متن کاملCorrection: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secretion in pancreatic beta cells. Sirt1 represses the uncoupling protein (UCP) gene UCP2 by binding d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2004
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.1.05675